REXULTI® (brexpiprazole)
Savings & Cost

Want to know what your prescription may cost? Let’s start with your insurance.

The list price, also known as the Wholesale Acquisition Cost (WAC), of REXULTI is $1,471.50 per month,* but most patients pay less with their prescription drug plan. 

Have commercial insurance? Pay as little
as $0 to start.

If you’ve been prescribed REXULTI and have commercial insurance, you may be eligible for the REXULTI Savings Card.† That means you could pay as little as:

$0  for REXULTI refills.

$0  for 90-day prescriptions.

Plus, pay as little as $0 per month for a generic antidepressant (if prescribed).

Click here to view Savings Terms & Conditions.

Ready to begin registration? Click the button below.

Register for Savings Card

Or we can text you a Savings Card – just send “SAVE” to 96747.‡

While your cost for REXULTI will depend on your specific plan, the average cost is $31.15 per month.†

Because each plan has different preferred drugs, out-of-pocket costs, and deductible requirements, talk to your insurance provider to find out your actual cost.

The REXULTI Savings Card can provide benefits for both REXULTI and a generic antidepressant.a,b

REXULTI

REXULTI refills as little as...............     $0

90-day prescriptions as little as.....     $0

Generic antidepressant

Your generic antidepressant for as little as............................... $0

Your generic antidepressant for as little as.... $0

(for up to 12 uses)

Covered generic antidepressants

Up to $8,180 applied to your annual deductible with up to 13 uses per calendar-year.
Benefit renews annually.**
Get reimbursed for your prescription by mail.

Using mail order or already paid for your prescription and need reimbursement?
Download and mail the Reimbursement Form.

DOWNLOAD FORM

Additional assistance

Have a prescription but not insured or need help paying for your REXULTI? Learn about additional assistance.§

Find Out More

Have more questions?

Read our FAQs or call us at 1-844-415-0674.
A representative will be available to help you 24/7.

SAVING CARD FAQS

*This is the price REXULTI is sold to wholesalers/pharmacies as of January 2024.
†Separate benefits. Subject to Savings Card terms and conditions.
aFor eligible commercially insured patients who are prescribed REXULTI. Benefits apply to copays, co-insurance, and pharmacy deductibles. Maximum annual benefit applies based on current list price. Click for full terms and conditions below.
bFor up to 12 uses.
**Terms and conditions apply.
‡Message and data rates apply. Message frequency varies. Text HELP for help and STOP to opt out. Otsuka may use pharmacy information to provide refill reminders with your consent. Click here for privacy policy.
§There is no guarantee that you will be approved for prescription assistance through the Otsuka Patient Assistance Foundation (OPAF). Additional information regarding insurance coverage and income may be needed before you receive approval.

Have Medicare?

With Medicare, out-of-pocket costs for REXULTI prescriptions average about $21.37 per month.† Of course, out-of-pocket costs vary throughout the year, depending on which phase of Part D you’re in and if you're enrolled in a Medicare Prescription Payment Plan (MPPP).

Your cost could be less if you’re eligible for the Social Security Administration’s Extra Help program.

Visit https://www.ssa.gov/‌benefits/‌medicare/‌prescriptionhelp/ for more information and to see if you qualify.

More about Medicare Part D

Find out what's changed

Download a guide to learn what's changing for
Medicare Part D in 2025.

Download guide

Additional assistance

Have a prescription but not insured or need help paying for your REXULTI? Learn about additional assistance.**

Find Out More

Have more questions?

Call us at 1-833-468-7852.
A representative will be available to help you 24/7.

*This is the price REXULTI is sold to wholesalers/pharmacies as of January 2024.
†Based on average patient price from Jan-December 2022.
**There is no guarantee that you will be approved for prescription assistance through the Otsuka Patient Assistance Foundation (OPAF). Additional information regarding insurance coverage and income may be needed before you receive approval.

Have Medicaid?

With Medicaid, the cost of REXULTI averages about $2.88 per month.† You may pay more or less depending on your state’s formulary.

To find out if you qualify for Medicaid, or to learn more about copayments in your state, visit https://www.medicaid.gov/‌state-overviews/‌index.html.

Additional assistance

Have a prescription but not insured or need help paying for your REXULTI? Learn about additional assistance.**

Find Out More

Have more questions?

Call us at 1-833-468-7852.
A representative will be available to help you 24/7.

*This is the price REXULTI is sold to wholesalers/pharmacies as of January 2024.
†Based on average patient price from Jan-December 2022.
**There is no guarantee that you will be approved for prescription assistance through the Otsuka Patient Assistance Foundation (OPAF). Additional information regarding insurance coverage and income may be needed before you receive approval.

Have insurance through Veterans Affairs benefits
or TRICARE?

With VA benefits or TRICARE, the cost of a REXULTI prescription averages $59.88 per month,† but your copay may vary depending on certain criteria and qualifications.

You may also be eligible to pay no copays. 

To find out if you qualify for VA benefits or TRICARE, or for more information about copayments, you can visit https://www.ebenefits.va.gov/‌ebenefits/‌homepage.

Additional assistance

Have a prescription but not insured or need help paying for your REXULTI? Learn about additional assistance.**

Find Out More

Have more questions?

Call us at 1-833-468-7852.
A representative will be available to help you 24/7.

*This is the price REXULTI is sold to wholesalers/pharmacies as of January 2024.
†Based on average patient price from Jan-December 2022.
**There is no guarantee that you will be approved for prescription assistance through the Otsuka Patient Assistance Foundation (OPAF). Additional information regarding insurance coverage and income may be needed before you receive approval.

Don’t have insurance coverage right now, or
your plan doesn’t cover REXULTI?

If you don’t have insurance or your plan doesn’t cover REXULTI, you can expect to pay the list price noted above, plus any applicable pharmacy charges.

Additional assistance

Have a prescription but not insured or need help paying for your REXULTI? Learn about additional assistance.†

Find Out More

Have more questions?

Call us at 1-833-468-7852.
A representative will be available to help you 24/7.

*This is the price REXULTI is sold to wholesalers/pharmacies as of January 2024.
†There is no guarantee that you will be approved for prescription assistance through the Otsuka Patient Assistance Foundation (OPAF). Additional information regarding insurance coverage and income may be needed before you receive approval.

ISI Block Title

IMPORTANT SAFETY INFORMATION AND INDICATIONS for REXULTI® (brexpiprazole)

IMPORTANT SAFETY INFORMATION:

  • Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of people with dementia-related psychosis without agitation that may happen with dementia due to Alzheimer’s disease.
  • Increased risk of suicidal thoughts and actions. REXULTI and antidepressant medicines may increase suicidal thoughts and actions in pediatric patients and young adult patients, especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions. All patients on antidepressants and their families or caregivers should closely watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. Report any change in these symptoms immediately to the doctor.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI.

REXULTI may cause serious side effects, including:

  • Cerebrovascular problems, including stroke, in elderly people with dementia-related psychosis that can lead to death.
  • Neuroleptic malignant syndrome (NMS) is a serious condition that can lead to death. Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS: high fever; changes in your pulse, blood pressure, heart rate, and breathing; stiff muscles; confusion; increased sweating
  • Uncontrolled body movements (tardive dyskinesia). REXULTI may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking REXULTI. Tardive dyskinesia may also start after you stop taking REXULTI.
  • Problems with your metabolism such as:
    • high blood sugar (hyperglycemia) and diabetes. Increases in blood sugar can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before you start, or soon after you start REXULTI and then regularly during long term treatment with REXULTI.

      Call your healthcare provider if you have any of these symptoms of high blood sugar during treatment with REXULTI:

      • feel very thirsty
      • feel very hungry
      • feel sick to your stomach
      • need to urinate more than usual
      • feel weak or tired
      • feel confused, or your breath
        smells fruity
    • increased fat levels (cholesterol and triglycerides) in your blood.
      Your healthcare provider should check the fat levels in your blood before you start, or soon after you start REXULTI, and then periodically during treatment with REXULTI.
    • weight gain. You and your healthcare provider should check your weight before you start and often during treatment with REXULTI.
  • Unusual and uncontrollable (compulsive) urges. Some people taking REXULTI have had strong unusual urges, to gamble and gambling that cannot be controlled (compulsive gambling). Other compulsive urges include sexual urges, shopping, and eating or binge eating. If you or your family members notice that you are having new or unusual strong urges or behaviors, talk to your healthcare provider.
  • Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with REXULTI.
  • Decreased blood pressure (orthostatic hypotension) and fainting. You may feel dizzy, lightheaded or pass out (faint) when you rise too quickly from a sitting or lying position.
  • Falls. REXULTI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries.
  • Seizures (convulsions).
  • Problems controlling your body temperature so that you feel too warm. Do not become too hot or dehydrated during treatment with REXULTI. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
  • Difficulty swallowing that can cause food or liquid to get into your lungs.
  • Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Do not drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.

Before taking REXULTI, tell your healthcare provider about all of your medical conditions, including if you:

  • have or have had heart problems or a stroke
  • have or have had low or high blood pressure
  • have or have had diabetes or high blood sugar or a family history of diabetes or high blood sugar.
  • have or have had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
  • have or have had seizures (convulsions)
  • have or have had kidney or liver problems
  • have or have had a low white blood cell count
  • are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy. 
    • Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with REXULTI.
    • There is a pregnancy exposure registry for women who are exposed to REXULTI during pregnancy. If you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Psychiatric Medications.
      You can register by calling 1-866-961-2388 or visit
      http://womensmentalhealth.org/‌clinical-and-research-programs/‌pregnancyregistry/.
  • are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with REXULTI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works. Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines during treatment with REXULTI without first talking to your healthcare provider.

The most common side effects of REXULTI include weight gain, sleepiness, dizziness, common cold symptoms, and restlessness or feeling like you need to move (akathisia).

These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report side effects of REXULTI (brexpiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1-800-438-9927 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

INDICATIONS: 

REXULTI is a prescription medicine used:

  • along with antidepressant medicines to treat major depressive disorder (MDD) in adults
  • to treat agitation that may happen with dementia due to Alzheimer’s disease

REXULTI should not be used as an “as needed” treatment for agitation that may happen with dementia due to Alzheimer’s disease.

It is not known if REXULTI is safe and effective in children with MDD.

Please read FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.

INDICATIONS: 

REXULTI is a prescription medicine used:

  • along with antidepressant medicines to treat major depressive disorder (MDD) in adults
  • to treat agitation that may happen with dementia due to Alzheimer’s disease

REXULTI should not be used as an “as needed” treatment for agitation that may happen with dementia due to Alzheimer’s disease.

It is not known if REXULTI is safe and effective in children with MDD.

INDICATIONS for REXULTI® (brexpiprazole)

REXULTI is a prescription medicine used:

  • along with antidepressant medicines to treat major depressive disorder (MDD) in adults
  • to treat agitation that may happen with dementia due to Alzheimer’s disease

REXULTI should not be used as an “as needed” treatment for agitation that may happen with dementia due to Alzheimer’s disease.

It is not known if REXULTI is safe and effective in children with MDD.

IMPORTANT SAFETY INFORMATION AND INDICATION for REXULTI® (brexpiprazole)

IMPORTANT SAFETY INFORMATION:

  • Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of people with dementia-related psychosis without agitation that may happen with dementia due to Alzheimer’s disease.
  • Increased risk of suicidal thoughts and actions. REXULTI and antidepressant medicines may increase suicidal thoughts and actions in pediatric patients and young adult patients, especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions. All patients on antidepressants and their families or caregivers should closely watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. Report any change in these symptoms immediately to the doctor.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI.

REXULTI may cause serious side effects, including:

  • Cerebrovascular problems, including stroke, in elderly people with dementia-related psychosis that can lead to death.
  • Neuroleptic malignant syndrome (NMS) is a serious condition that can lead to death. Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS: high fever; changes in your pulse, blood pressure, heart rate, and breathing; stiff muscles; confusion; increased sweating
  • Uncontrolled body movements (tardive dyskinesia). REXULTI may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop taking REXULTI. Tardive dyskinesia may also start after you stop taking REXULTI.
  • Problems with your metabolism such as:
    • high blood sugar (hyperglycemia) and diabetes. Increases in blood sugar can happen in some people who take REXULTI. Extremely high blood sugar can lead to coma or death. Your healthcare provider should check your blood sugar before you start, or soon after you start REXULTI and then regularly during long term treatment with REXULTI.

      Call your healthcare provider if you have any of these symptoms of high blood sugar during treatment with REXULTI:

      • feel very thirsty
      • feel very hungry
      • feel sick to your stomach
      • feel weak or tired
      • need to urinate more than usual
      • feel confused, or your breath smells fruity
    • increased fat levels (cholesterol and triglycerides) in your blood.
      Your healthcare provider should check the fat levels in your blood before you start, or soon after you start REXULTI, and then periodically during treatment with REXULTI.
    • weight gain. You and your healthcare provider should check your weight before you start and often during treatment with REXULTI.
  • Unusual and uncontrollable (compulsive) urges. Some people taking REXULTI have had strong unusual urges, to gamble and gambling that cannot be controlled (compulsive gambling). Other compulsive urges include sexual urges, shopping, and eating or binge eating. If you or your family members notice that you are having new or unusual strong urges or behaviors, talk to your healthcare provider.
  • Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with REXULTI.
  • Decreased blood pressure (orthostatic hypotension) and fainting. You may feel dizzy, lightheaded or pass out (faint) when you rise too quickly from a sitting or lying position.
  • Falls. REXULTI may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause fractures or other injuries.
  • Seizures (convulsions).
  • Problems controlling your body temperature so that you feel too warm. Do not become too hot or dehydrated during treatment with REXULTI. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
  • Difficulty swallowing that can cause food or liquid to get into your lungs.
  • Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Do not drive a car, operate machinery, or do other dangerous activities until you know how REXULTI affects you. REXULTI may make you feel drowsy.

Before taking REXULTI, tell your healthcare provider about all of your medical conditions, including if you:

  • have or have had heart problems or a stroke
  • have or have had low or high blood pressure
  • have or have had diabetes or high blood sugar or a family history of diabetes or high blood sugar.
  • have or have had high levels of total cholesterol, LDL cholesterol, or triglycerides, or low levels of HDL cholesterol
  • have or have had seizures (convulsions)
  • have or have had kidney or liver problems
  • have or have had a low white blood cell count
  • are pregnant or plan to become pregnant. REXULTI may harm your unborn baby. Taking REXULTI during your third trimester of pregnancy may cause your baby to have abnormal muscle movements or withdrawal symptoms after birth. Talk to your healthcare provider about the risk to your unborn baby if you take REXULTI during pregnancy. 
    • Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with REXULTI.
    • There is a pregnancy exposure registry for women who are exposed to REXULTI during pregnancy. If you become pregnant during treatment with REXULTI, talk to your healthcare provider about registering with the National Pregnancy Registry for Psychiatric Medications.
      You can register by calling 1-866-961-2388 or visit
      http://womensmentalhealth.org/‌clinical-and-research-programs/‌pregnancyregistry/.
  • are breastfeeding or plan to breastfeed. It is not known if REXULTI passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with REXULTI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REXULTI and other medicines may affect each other causing possible serious side effects. REXULTI may affect the way other medicines work, and other medicines may affect how REXULTI works. Your healthcare provider can tell you if it is safe to take REXULTI with your other medicines. Do not start or stop any medicines during treatment with REXULTI without first talking to your healthcare provider.

The most common side effects of REXULTI include weight gain, sleepiness, dizziness, common cold symptoms, and restlessness or feeling like you need to move (akathisia).

These are not all the possible side effects of REXULTI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report side effects of REXULTI (brexpiprazole). Please contact Otsuka America Pharmaceutical, Inc. at 1-800-438-9927 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

Please read FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.

 

 

 

INDICATIONS: 

REXULTI is a prescription medicine used:

  • along with antidepressant medicines to treat major depressive disorder (MDD) in adults
  • to treat agitation that may happen with dementia due to Alzheimer’s disease

REXULTI should not be used as an “as needed” treatment for agitation that may happen with dementia due to Alzheimer’s disease.

It is not known if REXULTI is safe and effective in children with MDD.